Publications

Chang Lab Publications at Cornell

29. Chang PV. "Microbial metabolite-receptor interactions in the gut microbiome." Curr Opin Chem Biol, DOI: https://doi.org/10.1016/j.cbpa.2024.102539, in press. Special issue on Chemical Microbiology.

28. Han L, Pendleton A, Singh A, Xu R, Scott SA, Palma JA, Diebold P, Malarney KP, Brito IL, Chang PV. "Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases." Cell Chem Biol, DOI: https://doi.org/10.1016/j.chembiol.2024.05.009, in press.

27. Han L, Xu R, Conwell AN, Takahashi S, Parasar B, Chang PV. "Bile salt hydrolase activity-based probes for monitoring gut microbial bile acid metabolism." ChemBioChem, DOI: 10.1002/cbic.202300821 (2024).

26. Scott SA, Fu J, Chang PV. "Dopamine receptor D2 confers colonization resistance via microbial metabolites." Nature, 628, 180-185 (2024).

25. Malarney KP, Chang PV. "Electrostatic interactions dictate bile salt hydrolase substrate preference." Biochemistry, 62, 3076-3084 (2023).

24. Carlson EE, Chang PV. "Probing the microbial world using chemical microbiology." Curr Opin Chem Biol, in press. Editorial overview for Chemical Microbiology special issue.

23. Han L, Chang PV. "Activity-based protein profiling in microbes and the gut microbiome." Curr Opin Chem Biol, 76, 102351 (2023). Special issue on Chemical Microbiology.

22. Malarney KP, Chang PV. "Chemoproteomic approaches for unraveling prokaryotic biology." Isr J Chem, 63, e202200076 (2023). Special issue in honor of Benjamin Cravatt for winning the 2022 Wolf Prize in Chemistry.

21. Zheng Q, Chang PV. "Shedding light on bacterial physiology with click chemistry." Isr J Chem, 63, e202200064 (2023). Special issue in honor of Carolyn Bertozzi for winning the 2022 Wolf Prize in Chemistry.

20. Parasar B, Chang PV. "BSH-TRAP: Bile salt hydrolase-tagging and retrieval with activity-based probes." Methods Enzymol, 664, 85-102 (2022). Special issue on Chemical Microbiology.

19. Parasar B, Chang PV. "Finding the sweet spot for breast cancer detection." ACS Cent Sci, 6, 2123-2125 (2020).

18. Parasar B, Chang PV. "Engineered Th17 cell differentiation using a photoactivatable immune modulator." J Am Chem Soc, 142, 18103-18108 (2020).

17. Scott SA, Fu J, Chang PV. "Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor." Proc Natl Acad Sci USA, 117, 19376-19387 (2020).

16. Chang PV. "Chemical mechanisms of colonization resistance by the gut microbial metabolome." ACS Chem Biol, 15, 1119-1126 (2020). Special issue on Chemical Microbiology.

15. Parasar B, Zhou H, Xiao X, Shi Q, Brito IL, Chang PV. "Chemoproteomic profiling of gut microbiota-associated bile salt hydrolase activity." ACS Cent Sci, 5, 867-873 (2019).

14. Nicolas GR and Chang PV. "Deciphering the chemical lexicon of host-gut microbiota interactions." Trends Pharmacol Sci, 40, 430-445 (2019). Featured on the cover.

13. Chang PV and Grimes CL. "Designer dendrons to dissect innate immune signaling." ACS Cent Sci, 4, 948-949 (2018).

12. Parasar B and Chang PV. "Chemical optogenetic modulation of inflammation and immunity." Chem Sci, 8, 1450-1453 (2017). 

Publications Prior to Cornell

11. Chang PV, Hao L, Offermanns S, Medzhitov R. “The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.” Proc Natl Acad Sci USA, 111, 2247-2252 (2014). Featured on the cover.

10. Chang PV and Bertozzi CR. “Imaging beyond the proteome.” Chem Commun, 48, 8864-8879 (2012).

9.  Chang PV, Dube DH, Sletten EM, Bertozzi CR. “A strategy for the selective imaging of glycans using caged metabolic precursors.” J Am Chem Soc, 132, 9516-9518 (2010). 

8.  Chang PV*, Prescher JA*, Sletten EM, Baskin JM, Miller IA, Agard NJ, Lo A, Bertozzi CR. “Copper-free click chemistry in living animals.” Proc Natl Acad Sci USA, 107, 1821-1826 (2010). (*equal contribution)

7.  Chang PV*, Chen X*, Smyrniotis C, Xenakis A, Hu T, Bertozzi CR, Wu P. “Metabolic labeling of sialic acids in living animals with alkynyl sugars.” Angew Chem Int Ed, 48, 4030-4033 (2009).

6.  Guggenheim ER, Xu D, Zhang CX, Chang PV, Lippard SJ. “Photo-affinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA.” ChemBioChem, 10, 141-157 (2009).

5.  Drake PM, Nathan JK, Stock CM, Chang PV, Muench MO, Nakata D, Reader JR, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Troy II FA, Bertozzi CR. “Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.” J Immunol, 181, 6850-6858 (2008).

4.  Chang PV, Prescher JA, Hangauer MJ, Bertozzi CR. “Imaging cell surface glycans with bioorthogonal chemical reporters.” J Am Chem Soc, 129, 8400-8401 (2007).

3.  Baskin JM, Prescher JA, Laughlin ST, Agard NJ, Chang PV, Miller IA, Lo A, Codelli JA, Bertozzi CR. “Copper-free click chemistry for dynamic in vivo imaging.” Proc Natl Acad Sci USA, 104, 16793-16797 (2007).

2.  Laughlin ST, Agard NJ, Baskin JM, Carrico IS, Chang PV, Ganguli AS, Hangauer MJ, Lo A, Prescher JA, Bertozzi CR. “Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics.” Methods Enzymol, 415, 230-250 (2006). 

1.  Zhang CX, Chang PV, Lippard SJ. “Identification of nuclear proteins that interact with platinum-modified DNA by photoaffinity labeling.” J Am Chem Soc, 126, 6536-6537 (2004).